Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11097045 | 0.92 | LMNA (0.36) | MEN1HTTKMT2AGSK3BALDH1A1 | |
| SCHEMBL7326811 | 0.83 | GSK3B (0.39) | GSK3BTP53 | |
| SCHEMBL11102771 | 0.73 | CA2 (0.31) | — | |
| SCHEMBL11014231 | 0.73 | OPRK1 (0.37) | MEN1HTTKMT2AMMP2ADCY2 | |
| SCHEMBL10509753 | 0.71 | ALOX15 (0.50) | MEN1HTTKMT2ABCHEACHE | |
| SCHEMBL10808149 | 0.67 | ITGB2 (0.55) | MEN1KMT2AACHEALDH1A1TP53 | |
| SCHEMBL10648947 | 0.66 | HTT (0.57) | MEN1HTTKMT2AMAPTNPSR1 | |
| SCHEMBL10508894 | 0.65 | ALOX15 (0.41) | MEN1HTTKMT2ABCHEACHE | |
| SCHEMBL3346744 | 0.65 | OPRK1 (0.40) | MEN1HTTKMT2ABCHEACHE | |
| SCHEMBL10653418 | 0.64 | CA2 (0.53) | MEN1HTTKMT2ABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021773-B1 | THIAZOLO (2,3-B) BENZO (AND AZABENZO) THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-01 | — | — | EP | claimed |
| US-4275065-A | USEFUL FOR SKIN GRAFTS AND ORGAN TRANSPLANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-06-23 | — | — | US | claimed |
| EP-0021773-A1 | Thiazolo (2,3-b) benzo (and azabenzo) thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-07 | — | — | EP | claimed |
| US-4866082-A | Inhibition of bone loss by (-)-N-[[(5-chloro-2-benzothiazolyl)thio]phenylacetyl]-L-cysteine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| EP-0067685-B1 | ALPHA-PHENYL-2-(AZA)BENZOTHIAZOLYLTHIOGLYCOLIC ACIDS AND DERIVATIVES THEREOF | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-11-05 | — | — | EP | disclosed |
| US-4609667-A | Inhibitor of mammalian collagenase and elastase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-09-02 | — | — | US | disclosed |
| US-4567267-A | α-Phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0021773-B1 | THIAZOLO (2,3-B) BENZO (AND AZABENZO) THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-01 | — | — | EP | disclosed |
| EP-0067685-A1 | Alpha-phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-12-22 | — | — | EP | disclosed |
| US-4275065-A | USEFUL FOR SKIN GRAFTS AND ORGAN TRANSPLANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-06-23 | — | — | US | disclosed |
| EP-0021773-A1 | Thiazolo (2,3-b) benzo (and azabenzo) thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-07 | — | — | EP | disclosed |