Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CEL | P19835 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.31 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4458509 | 0.74 | CEL (0.35) | LMNACELPTGDR2CAMKK1CAMKK2 | |
| SCHEMBL4580554 | 0.72 | ALDH1A1 (0.42) | LMNACELMEN1MAPTKMT2A | |
| SCHEMBL28849763 | 0.72 | ALDH1A1 (0.42) | LMNACELMEN1MAPTKMT2A | |
| SCHEMBL18825949 | 0.70 | KDR (0.30) | — | |
| SCHEMBL2830912 | 0.69 | KEAP1 (0.40) | LMNACELTDO2NEK2 | |
| SCHEMBL8167373 | 0.69 | LMNA (0.36) | LMNACELMAPTCAMKK1CAMKK2 | |
| SCHEMBL29958546 | 0.69 | LMNA (0.36) | LMNACELCAMKK1CAMKK2NEK2 | |
| SCHEMBL8167370 | 0.69 | LMNA (0.42) | LMNAKDM4EMEN1MAPTKMT2A | |
| SCHEMBL29287140 | 0.68 | CEL (0.35) | LMNACELMAPTPTGDR2CAMKK1 | |
| SCHEMBL18825990 | 0.68 | CEL (0.35) | LMNACELKDM4EMAPTPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009117-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELLIX NEUROSCIENCE INC. (US) | 2001-02-08 | — | — | WO | disclosed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |