Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328956 | 0.94 | ALDH1A1 (0.56) | KDM4EALDH1A1KMT2ASMN1; SMN2THRB | |
| SCHEMBL16370933 | 0.77 | L3MBTL1 (0.71) | KDM4EALDH1A1KMT2ASMN1; SMN2LMNA | |
| Oxalic Acid SCHEMBL7328932 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7327720 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22639809 | 0.70 | L3MBTL1 (0.67) | MEN1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL22639911 | 0.70 | L3MBTL1 (0.67) | MEN1KMT2ASMN1; SMN2LMNAMAPK1 | |
| Oxalic Acid SCHEMBL7328948 | 0.69 | DRD4 (0.54) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7328952 | 0.66 | KDM4E (0.52) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7328937 | 0.66 | KDM4E (0.44) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Oxalic Acid SCHEMBL729184 | 0.65 | SIGMAR1 (0.91) | SMN1; SMN2LMNAMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |