Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | IDUA | P35475 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CAD | P27708 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629491 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL31697657 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL4629492 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL19850672 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL7282443 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL31694886 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL9747922 | 0.79 | IDUA (0.34) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10411814 | 0.78 | ALDH1A1 (0.41) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL14551177 | 0.78 | ALDH1A1 (0.41) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL12974414 | 0.77 | CRBN (0.33) | ITGB1ITGA5ITGB3ITGB2ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9428458-B2 | Substituted pyridoxine-lactam carboxylate-salts | ALCOBRA LTD. (IL) | 2016-08-30 | — | — | US | disclosed |
| US-20160199362-A1 | METHOD FOR THE TREATMENT, ALLEVIATION OF SYMPTOMS OF, RELIEVING, IMPROVING AND PREVENTING A COGNITIVE DISEASE, DISORDER OR CONDITION | ALCOBRA LTD. (IL) | 2016-07-14 | — | — | US | disclosed |
| US-20160199362-A1 | METHOD FOR THE TREATMENT, ALLEVIATION OF SYMPTOMS OF, RELIEVING, IMPROVING AND PREVENTING A COGNITIVE DISEASE, DISORDER OR CONDITION | ALCOBRA LTD. (IL) | 2016-07-14 | — | — | US | disclosed |
| US-20150025111-A1 | SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE-SALTS | ALCOBRA LTD. (IL) | 2015-01-22 | — | — | US | disclosed |
| US-8889715-B2 | Substituted pyridoxine-lactam carboxylate salts | ALCOBRA LTD. (IL) | 2014-11-18 | — | — | US | disclosed |
| US-8710067-B2 | Method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition | ALCOBRA LTD. (IL) | 2014-04-29 | — | — | US | disclosed |
| US-20130059887-A1 | SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS | ALCOBRA LTD. (IL) | 2013-03-07 | — | — | US | disclosed |
| US-20110294859-A1 | SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS | ALCOBRA LTD. (IL) | 2011-12-01 | — | — | US | disclosed |
| US-20080108830-A1 | Production method of optically active 2-[(N-benzylprolyl)amino]benzo-phenone compound | AJINOMOTO CO. INC (JP) | 2008-05-08 | — | — | US | disclosed |
| EP-1918276-A1 | Production method of optically active 2- [ (N-Benzylprolyl) Amino ] Benzophenone compound | Ajinomoto Co., Inc. (JP) | 2008-05-07 | — | — | EP | disclosed |
| US-5151497-A | Central nervous system disorders, antidepressants, epilepsy and cognition activators | JAPAN TOBACCO INC. (JP) | 1992-09-29 | — | — | US | disclosed |
| EP-0384380-A2 | Novel peptide derivatives and their pharmaceutical use | JAPAN TOBACCO INC. (JP) | 1990-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059887-A1 | SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS | PLPBP, PNPO, ADH5 | ITGB1 2629/4885ITGA5 407/4885ITGB3 2306/4885 |
| US-20080108830-A1 | Production method of optically active 2-[(N-benzylprolyl)amino]benzo-phenone compound | NPEPPS, SYMPK, REN | ITGB1 4499/4885ITGA5 3077/4885ITGB3 4285/4885 |
| US-20160199362-A1 | METHOD FOR THE TREATMENT, ALLEVIATION OF SYMPTOMS OF, RELIEVING, IMPROVING AND PREVENTING A COGNITIVE DISEASE, DISORDER OR CONDITION | ACHE, BCHE, GRIK5 | ITGB1 4749/4885ITGA5 3429/4885ITGB3 4863/4885 |
| US-20150025111-A1 | SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE-SALTS | PNPO, PLPBP, NQO1 | ITGB1 2373/4885ITGA5 299/4885ITGB3 2108/4885 |
| US-20110294859-A1 | SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS | PLPBP, PNPO, ADH5 | ITGB1 2629/4885ITGA5 407/4885ITGB3 2306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.