SCHEMBL7332808

SCHEMBL7332808

CCCCCCOc1ccc(N2CCC(=O)C(C(=O)OCC)C2)cc1

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
HSP90AA1 P07900 2/20 0.52
S1PR5 Q9H228 9/20 0.43
S1PR1 P21453 6/20 0.43
S1PR3 Q99500 4/20 0.43
THRA P10827 2/20 0.43
THRB P10828 2/20 0.43
PLA2G2A P14555 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10687043 0.84 ALDH1A1 (0.51) ALDH1A1THRB
SCHEMBL8912051 0.83 ALDH1A1 (0.44) ALDH1A1
SCHEMBL11846643 0.78 LIPE (0.42) ALDH1A1
SCHEMBL10689619 0.78 ALDH1A1 (0.42) ALDH1A1
SCHEMBL7337356 0.75 LTA4H (0.52) ALDH1A1THRATHRBPLA2G2A
SCHEMBL15019849 0.75 LTA4H (0.52) ALDH1A1THRATHRBPLA2G2A
SCHEMBL3548031 0.75 MEN1 (0.45) ALDH1A1
SCHEMBL6538754 0.74 THRA (0.59) ALDH1A1THRATHRBPLA2G2A
SCHEMBL31067226 0.73 LMNA (0.43) ALDH1A1
SCHEMBL17107439 0.73 THRB (0.67) ALDH1A1THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788511-B1 CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO (JP) 2002-12-11 EP disclosed
US-6265536-B1 MICROBIOCIDE AND FUNGICIDE WHICH IS INHIBITOR OF BETA-1,3-GLUCAN SYNTHASE; TREATMENT OF PNEUMOCYSTIS CARINII INFECTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-07-24 US disclosed
US-6107458-A FUNGICIDE WHICH IS BETA-1,3-GLYCAN SYNTHASE INHIBITOR; FOR PROPHYLAXIS AND TREATMENT OF PNEUMOCYSTIS CARINII INFECTIONS LIKE PNEUMONIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-08-22 US disclosed
EP-0788511-A1 CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-08-13 EP disclosed
WO-1996011210-A1 CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-04-18 WO disclosed