Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9224285 | 0.96 | CASP1 (0.47) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL9223556 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AHDAC8HDAC2 | |
| SCHEMBL9223995 | 0.85 | ITGB3 (0.46) | SMN1; SMN2LMNARAB9ACASP1HDAC8 | |
| SCHEMBL7331480 | 0.85 | ITGB3 (0.42) | KMT2ASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8886008 | 0.83 | MAPT (0.49) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL9217465 | 0.79 | L3MBTL1 (0.43) | MEN1KMT2AMAPTRAB9AHDAC8 | |
| SCHEMBL7300054 | 0.79 | L3MBTL1 (0.43) | MEN1KMT2AMAPTRAB9AHDAC8 | |
| SCHEMBL7299527 | 0.78 | ITGB3 (0.44) | MEN1KMT2ACASP1HDAC8HDAC3 | |
| SCHEMBL9221804 | 0.78 | ITGB3 (0.44) | MEN1KMT2ACASP1HDAC8HDAC3 | |
| SCHEMBL7305875 | 0.77 | ACE (0.49) | MAPTHDAC8HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |