Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | SFN | P31947 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331480 | 0.85 | ITGB3 (0.42) | MAPTRAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL8408125 | 0.83 | CTSL (0.41) | MAPTKMT2AALDH1A1SMN1; SMN2CTSS | |
| SCHEMBL9223556 | 0.83 | SMN1; SMN2 (0.43) | RAB9ANPC1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL7333071 | 0.83 | MEN1 (0.43) | MAPTRAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL9252697 | 0.82 | HDAC6 (0.42) | MAPTKMT2ASMN1; SMN2MEN1TP53 | |
| SCHEMBL11714376 | 0.81 | CTSK (0.61) | MAPTRAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL9224285 | 0.79 | CASP1 (0.47) | MAPTRAB9ANPC1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8885572 | 0.79 | ITGB3 (0.56) | RAB9APOLBCTDSP1NPC1SFN | |
| SCHEMBL9568122 | 0.78 | CTSS (0.43) | MAPTRAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL8885312 | 0.77 | MAPT (0.55) | MAPTRAB9APOLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |