Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333071 | 0.96 | MEN1 (0.43) | CASP1ITGB3ITGA2BMEN1KMT2A | |
| SCHEMBL9223556 | 0.88 | SMN1; SMN2 (0.43) | ITGB3ITGA2BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7331480 | 0.82 | ITGB3 (0.42) | ITGB3ITGA2BKMT2ASMN1; SMN2MAPT | |
| SCHEMBL9223995 | 0.81 | ITGB3 (0.46) | CASP1ITGB3ITGA2BSMN1; SMN2LMNA | |
| SCHEMBL7336397 | 0.80 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL8886008 | 0.79 | MAPT (0.49) | ITGB3ITGA2BMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9220637 | 0.77 | CASP1 (0.55) | CASP1HDAC8 | |
| SCHEMBL9217465 | 0.76 | L3MBTL1 (0.43) | ITGB3MEN1KMT2AMAPTRAB9A | |
| SCHEMBL7300054 | 0.76 | L3MBTL1 (0.43) | ITGB3MEN1KMT2AMAPTRAB9A | |
| SCHEMBL7306359 | 0.76 | PRSS1 (0.46) | ITGB3MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |