Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 7/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 8/20 | 0.42 |
| ▸ | MMP3 | P08254 | 8/20 | 0.42 |
| ▸ | MMP1 | P03956 | 7/20 | 0.42 |
| ▸ | MMP7 | P09237 | 7/20 | 0.42 |
| ▸ | MMP9 | P14780 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335195 | 1.00 | MMP13 (0.52) | MMP13ADAMTS4ADAM17GAAMAPT | |
| SCHEMBL7336565 | 0.83 | ADAM17 (0.46) | MMP13ADAMTS4ADAM17ALDH1A1MMP1 | |
| SCHEMBL4331283 | 0.79 | ADAMTS4 (0.49) | MMP13ADAMTS4GAAMAPTALDH1A1 | |
| SCHEMBL4331282 | 0.79 | ADAMTS4 (0.49) | MMP13ADAMTS4GAAMAPTALDH1A1 | |
| SCHEMBL7401699 | 0.79 | CA2 (0.51) | ADAM17ALDH1A1 | |
| SCHEMBL7332493 | 0.79 | CA2 (0.51) | ADAM17ALDH1A1 | |
| SCHEMBL7332133 | 0.77 | ADAMTS4 (0.55) | MMP13ADAMTS4MAPTALDH1A1MMP2 | |
| SCHEMBL7332138 | 0.77 | ADAMTS4 (0.55) | MMP13ADAMTS4MAPTALDH1A1MMP2 | |
| SCHEMBL14843359 | 0.73 | ALDH1A1 (0.49) | MMP13ADAMTS4GAAMAPTALDH1A1 | |
| SCHEMBL14843210 | 0.73 | ALDH1A1 (0.49) | MMP13ADAMTS4GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |