Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333358 | 0.91 | HTR1A (0.48) | SIGMAR1HTR1ADRD2PARP1KDM4E | |
| Fumaric Acid SCHEMBL9375443 | 0.90 | SIGMAR1 (0.46) | SIGMAR1HTR1ADRD3PARP1KDM4E | |
| Maleic Acid SCHEMBL9375437 | 0.90 | SIGMAR1 (0.46) | SIGMAR1HTR1ADRD3PARP1KDM4E | |
| SCHEMBL9735887 | 0.87 | PARP1 (0.45) | SIGMAR1HTR1ADRD3DRD2PARP1 | |
| SCHEMBL9372501 | 0.87 | SIGMAR1 (0.52) | SIGMAR1HTR1ADRD2PARP1 | |
| SCHEMBL7299309 | 0.84 | SIGMAR1 (0.49) | SIGMAR1DRD3PARP1KDM4EKMT2A | |
| SCHEMBL7297853 | 0.83 | SIGMAR1 (0.48) | SIGMAR1HTR1ADRD2KDM4EKMT2A | |
| SCHEMBL9371817 | 0.82 | HTR1A (0.56) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL7304233 | 0.81 | SIGMAR1 (0.49) | SIGMAR1HTR1ADRD3KMT2AHSD17B10 | |
| SCHEMBL7335481 | 0.79 | SIGMAR1 (0.47) | SIGMAR1HTR1APARP1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149817-A | Psychotropic agents | SHIONOGI & CO., LTD. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445701-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |