Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9375443 | 1.00 | SIGMAR1 (0.46) | SIGMAR1HTR1AHTR7DRD3KDM4E | |
| SCHEMBL7335487 | 0.90 | SIGMAR1 (0.47) | SIGMAR1HTR1AHTR7DRD3KDM4E | |
| SCHEMBL9372501 | 0.85 | SIGMAR1 (0.52) | SIGMAR1HTR1APARP1 | |
| SCHEMBL7333358 | 0.83 | HTR1A (0.48) | SIGMAR1HTR1AHTR7KDM4EPARP1 | |
| SCHEMBL7299309 | 0.82 | SIGMAR1 (0.49) | SIGMAR1DRD3KDM4EKMT2AMEN1 | |
| SCHEMBL7297853 | 0.82 | SIGMAR1 (0.48) | SIGMAR1HTR1AHTR7KDM4EKMT2A | |
| SCHEMBL9735887 | 0.80 | PARP1 (0.45) | SIGMAR1HTR1AHTR7DRD3PARP1 | |
| SCHEMBL7304233 | 0.79 | SIGMAR1 (0.49) | SIGMAR1HTR1AHTR7DRD3KMT2A | |
| SCHEMBL9371817 | 0.79 | HTR1A (0.56) | SIGMAR1HTR1A | |
| SCHEMBL7335481 | 0.73 | SIGMAR1 (0.47) | SIGMAR1HTR1AHTR7KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304330-B1 | Carbamoylpyrrolidone derivatives, their use and preparation | SHIONOGI & CO (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5202345-A | Carbamoylpyrrolidone derivatives and drugs for senile dementia | SHIONOGI & CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| US-5120733-A | Cognition activators and psychological disorders | SHIONOGI AND CO. LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0304330-A1 | Carbamoylpyrrolidone derivatives, their use and preparation | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-02-22 | — | — | EP | disclosed |