Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372501 | 0.94 | SIGMAR1 (0.52) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7297853 | 0.84 | SIGMAR1 (0.48) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7333358 | 0.83 | HTR1A (0.48) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7335487 | 0.82 | SIGMAR1 (0.47) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7299309 | 0.81 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL9735887 | 0.80 | PARP1 (0.45) | HTR1ASIGMAR1DRD2 | |
| Maleic Acid SCHEMBL9375437 | 0.79 | SIGMAR1 (0.46) | HTR1ASIGMAR1 | |
| Fumaric Acid SCHEMBL9375443 | 0.79 | SIGMAR1 (0.46) | HTR1ASIGMAR1 | |
| SCHEMBL7304233 | 0.78 | SIGMAR1 (0.49) | HTR1ASIGMAR1 | |
| SCHEMBL9371421 | 0.76 | DRD2 (0.59) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304330-B1 | Carbamoylpyrrolidone derivatives, their use and preparation | SHIONOGI & CO (JP) | 1994-03-30 | — | — | EP | claimed |
| US-4977167-A | Alzheimer*s disease | SHIONOGI & CO., LTD. (JP) | 1990-12-11 | — | — | US | claimed |
| EP-0304330-B1 | Carbamoylpyrrolidone derivatives, their use and preparation | SHIONOGI & CO (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5202345-A | Carbamoylpyrrolidone derivatives and drugs for senile dementia | SHIONOGI & CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| US-5120733-A | Cognition activators and psychological disorders | SHIONOGI AND CO. LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0304330-A1 | Carbamoylpyrrolidone derivatives, their use and preparation | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-02-22 | — | — | EP | disclosed |