SCHEMBL7341065

SCHEMBL7341065

Cc1cccc(Nc2ccccc2C=O)c1C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.54
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
CYP2C9 P11712 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
PTGS2 P35354 2/20 0.54
AKR1B10 O60218 1/20 0.54
TRPA1 O75762 1/20 0.54
ABCB11 O95342 1/20 0.54
DHFR P00374 1/20 0.54
MPO P05164 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CHRM1 P11229 1/20 0.54
AKR1B1 P15121 1/20 0.54
PTGS1 P23219 1/20 0.54
AKR1C3 P42330 1/20 0.54
AKR1C2 P52895 1/20 0.54
AKR1C1 Q04828 1/20 0.54
HIF1A Q16665 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14306858 0.89 ALDH1A1 (0.47) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL10695412 0.87 ALDH1A1 (0.59) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL7760481 0.84 ALDH1A1 (0.55) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL26725771 0.83 MT-CO2 (0.56) LMNAMEN1KMT2ACYP2C9PTGS2
SCHEMBL4333864 0.82 LMNA (0.60) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL1922753 0.80 LMNA (0.63) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL4189645 0.80 RAPGEF4 (0.65) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL14306856 0.79 PDCD1 (0.42) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL11403543 0.78 KMT2A (0.61) LMNAMEN1KMT2ACYP2C9TDP1
SCHEMBL7349226 0.78 LMNA (0.50) LMNAMEN1KMT2ACYP2C9TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4272761-A2 COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS Medicon Pharmaceuticals, Inc. (US) 2023-11-08 EP disclosed
WO-2010009215-A1 NICOTINIC ACID RECEPTOR AGONIST COMPOUNDS USEFUL TO TREAT METABOLIC SYNDROMES SCHERING CORPORATION (US) 2010-01-21 WO disclosed
WO-2010009212-A1 NIACIN DERIVATIVES USEFUL TO TREAT METABOLIC SYNDROMES SCHERING CORPORATION (US) 2010-01-21 WO disclosed
US-5112846-A Nonsteroidal antiinflammatory agents WARNER-LAMBERT COMPANY (US) 1992-05-12 US disclosed
US-5075330-A N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents WARNER-LAMBERT CO. (US) 1991-12-24 US disclosed
US-4981865-A N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents WARNER-LAMBERT CO. (US) 1991-01-01 US disclosed
US-4711879-A IMMUNO-MODULATING ACTIVITY CIBA-GEIGY CORPORATION (US) 1987-12-08 US disclosed
US-4640911-A IMMUNOSTIMULANTS, VIRICIDES SUCH AS HERPES SIMPLEX CIBA-GEIGY CORPORATION (US) 1987-02-03 US disclosed
US-4546106-A ANTIARTHRITIC AGENTS MERCK & CO., INC. (US) 1985-10-08 US disclosed
US-4355034-A Ethenyl derivatives of mercaptoalkylpyridines as anti-inflammatory agents MERCK & CO., INC. (US) 1982-10-19 US disclosed
US-4217352-A ANTIARTHRITIC AGENT MERCK & CO., INC. (US) 1980-08-12 US disclosed
US-4212976-A ANTIARTHRITIC AGENTS MERCK & CO., INC. (US) 1980-07-15 US disclosed
US-4144342-A ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS MERCK & CO., INC. (US) 1979-03-13 US disclosed
US-4061759-A ANTIINFLAMMATORY, ARTHRITIS MERCK & CO., INC. (US) 1977-12-06 US disclosed
US-4057637-A RHEUMATOID ARTHRITIS MERCK & CO., INC. (US) 1977-11-08 US disclosed
US-3971797-A ANTIARTHRITIC MERCK & CO., INC. (US) 1976-07-27 US disclosed