Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LIPE | Q05469 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339364 | 0.89 | ALDH1A1 (0.56) | SMN1; SMN2MAPTLMNAKMT2ANPC1 | |
| SCHEMBL7343260 | 0.88 | MAPT (0.51) | SMN1; SMN2MAPTLMNACYP4Z1KMT2A | |
| SCHEMBL7346082 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTLMNACYP4Z1KMT2A | |
| SCHEMBL17653809 | 0.87 | LMNA (0.62) | SMN1; SMN2MAPTLMNACYP4Z1KMT2A | |
| SCHEMBL68851 | 0.81 | CYP4Z1 (0.62) | SMN1; SMN2MAPTLMNACYP4Z1KMT2A | |
| SCHEMBL7338660 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAKMT2AMEN1HTT | |
| SCHEMBL4047050 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL28902573 | 0.79 | LOXL2 (0.56) | SMN1; SMN2MAPTLMNACYP4Z1KMT2A | |
| SCHEMBL11055879 | 0.79 | SMN1; SMN2 (0.73) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL6393097 | 0.78 | ALDH1A1 (0.57) | SMN1; SMN2MAPTLMNACYP4Z1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622984-A | INHIBITORS OF PHOSPHOLIPASE, VARIOUS PROTEASES | ONO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1997-04-22 | — | — | US | disclosed |
| US-5614555-A | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0588655-B1 | Amidinophenol derivatives | ONO PHARMACEUTICAL CO (JP) | 1996-12-04 | — | — | EP | disclosed |
| EP-0588655-A1 | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |