Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823384 | 0.91 | ALDH1A1 (0.40) | GPR139SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL7345869 | 0.88 | HTT (0.43) | GPR139SMN1; SMN2KDM4EMAPTNPC1 | |
| SCHEMBL7339213 | 0.86 | MEN1 (0.46) | KDM4EMAPTNPC1GAARAB9A | |
| SCHEMBL6773894 | 0.85 | ITGB3 (0.47) | GPR139KDM4EITGB3ITGAVITGB1 | |
| SCHEMBL6779571 | 0.84 | FPR2 (0.43) | NPC1GAARAB9AITGB3ITGAV | |
| SCHEMBL7347036 | 0.84 | HPGD (0.42) | GPR139SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL6773776 | 0.83 | CTSB (0.43) | KDM4EMAPTNPC1GAARAB9A | |
| SCHEMBL6778010 | 0.82 | GPR139 (0.49) | GPR139SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL6782093 | 0.81 | ITGB1 (0.41) | GPR139ITGB3ITGAVITGB1ITGB5 | |
| SCHEMBL7340359 | 0.81 | GPR139 (0.40) | GPR139SMN1; SMN2MAPTITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |