Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.47 |
| ▸ | MMP2 | P08253 | 8/20 | 0.47 |
| ▸ | MMP3 | P08254 | 8/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 10/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340578 | 0.78 | MMP2 (0.49) | MMP2MMP3MMP13MMP1MMP9 | |
| SCHEMBL7371953 | 0.69 | MMP2 (0.56) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7364753 | 0.68 | ALDH1A1 (0.49) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7207785 | 0.66 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL4796904 | 0.66 | ALDH1A1 (0.49) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7207560 | 0.66 | MMP13 (0.75) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7380941 | 0.65 | SLC1A3 (0.54) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7208714 | 0.65 | MMP1 (0.48) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL29540673 | 0.65 | MMP2 (0.73) | MMP2MMP3MMP13MMP1MMP9 | |
| SCHEMBL6323452 | 0.65 | MMP2 (0.73) | MMP2MMP3MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5455258-A | Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |