Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30504671 | 0.89 | ESR1 (0.34) | ALDH1A1 | |
| SCHEMBL15689666 | 0.79 | IDO1 (0.39) | ALDH1A1SMN1; SMN2HPGDCTSL | |
| SCHEMBL4400588 | 0.78 | TRPA1 (0.41) | ALOX5KDM4EALDH1A1 | |
| SCHEMBL6748003 | 0.78 | TRPA1 (0.41) | ALOX5KDM4EALDH1A1 | |
| SCHEMBL12157425 | 0.78 | TRPA1 (0.41) | ALOX5KDM4EALDH1A1 | |
| SCHEMBL31353465 | 0.78 | CYP2A6 (0.40) | ALOX5KDM4EPYCR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16177721 | 0.78 | CYP2A6 (0.40) | ALOX5KDM4EPYCR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3322412 | 0.78 | CYP2A6 (0.40) | ALOX5KDM4EPYCR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15368378 | 0.73 | KMT2A (0.39) | ALOX5KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL20437579 | 0.72 | ADRB1 (0.33) | KDM4EALDH1A1SMN1; SMN2HPGDHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975447-B2 | Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-10 | — | — | US | disclosed |
| US-8883778-B2 | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20140171692-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-19 | — | — | US | disclosed |
| US-8754076-B2 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | Vitae Pharmaceuticals, Inc./Boehringer-Ingelheim (DE) | 2014-06-17 | — | — | US | disclosed |
| US-8680093-B2 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8673899-B2 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8629138-B2 | — | — | 2014-01-14 | — | — | US | disclosed |
| US-8575157-B2 | — | — | 2013-11-05 | — | — | US | disclosed |
| US-8575156-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8569292-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120178746-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. Boehringer Ingelheim International GmbH | 2012-07-12 | — | — | US | disclosed |
| US-20120108579-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8138178-B2 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20120040973-A1 | DERIVATIVES OF [1,3]OXAZIN-2-ONE USEFUL FOR THE TREATMENT OF METABOLIC DISEASES SUCH AS LIPID DISORDERS | VITAE PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-8114868-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2012-02-14 | — | — | US | disclosed |
| US-20110269957-A1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110263584-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | Vitae Pharmaceuticals, Inc. Boehringer Ingelheim International GmbH | 2011-10-27 | — | — | US | disclosed |
| US-20110263583-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. | 2011-10-27 | — | — | US | disclosed |
| US-20110021512-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. | 2011-01-27 | — | — | US | disclosed |
| US-20110009402-A1 | Cyclic Inhibitors of 11Beta-Hydroxysteroid Dehydrogenase 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021512-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD11B2, HSD3B1 | ALOX5 46/4885KDM4E 3273/4885PYCR1 477/4885 |
| US-20110263584-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD17B1, HSD11B2 | ALOX5 2351/4885KDM4E 3785/4885PYCR1 404/4885 |
| US-20120108579-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | ALOX5 43/4885KDM4E 2592/4885PYCR1 596/4885 |
| US-20110269957-A1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD11B2 | ALOX5 597/4885KDM4E 3324/4885PYCR1 846/4885 |
| US-20140171692-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST | HSD11B1, HSD11B2, HSD17B1 | ALOX5 2194/4885KDM4E 941/4885PYCR1 383/4885 |
| US-20110009402-A1 | Cyclic Inhibitors of 11Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD11B2, HSD3B1 | ALOX5 223/4885KDM4E 3461/4885PYCR1 356/4885 |
| US-20120040973-A1 | DERIVATIVES OF [1,3]OXAZIN-2-ONE USEFUL FOR THE TREATMENT OF METABOLIC DISEASES SUCH AS LIPID DISORDERS | HSD11B1, HSD11B2, HSD17B1 | ALOX5 453/4885KDM4E 3015/4885PYCR1 203/4885 |
| US-20110263583-A1 | Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD11B2, HSD17B3 | ALOX5 231/4885KDM4E 2353/4885PYCR1 924/4885 |
| US-20120178746-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | ALOX5 223/4885KDM4E 3441/4885PYCR1 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.