Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.45 |
| ▸ | MMP1 | P03956 | 9/20 | 0.45 |
| ▸ | MMP14 | P50281 | 7/20 | 0.45 |
| ▸ | MMP3 | P08254 | 6/20 | 0.45 |
| ▸ | MMP8 | P22894 | 5/20 | 0.45 |
| ▸ | MMP2 | P08253 | 13/20 | 0.44 |
| ▸ | MMP13 | P45452 | 6/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MMP10 | P09238 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923030 | 0.79 | MMP9 (0.53) | MMP9MMP1MMP3MMP8MMP2 | |
| SCHEMBL8001764 | 0.73 | MMP9 (0.46) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL7990360 | 0.71 | MMP9 (0.60) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL8000267 | 0.71 | MMP13 (0.75) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL7365907 | 0.70 | MMP2 (0.48) | MMP9MMP1MMP14MMP3MMP2 | |
| SCHEMBL8002774 | 0.70 | MMP9 (0.50) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL8001945 | 0.69 | MMP14 (0.60) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL7990314 | 0.69 | MMP9 (0.52) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL8000236 | 0.68 | MMP9 (0.60) | MMP9MMP1MMP14MMP3MMP8 | |
| SCHEMBL8005756 | 0.68 | MMP2 (0.50) | MMP9MMP1MMP14MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | claimed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | claimed |
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |