Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 6/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 9/20 | 0.39 |
| ▸ | MMP3 | P08254 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357691 | 0.91 | CTSL (0.45) | CTSLMMP1PSMB5MMP8PSMB1 | |
| SCHEMBL7360065 | 0.85 | MMP1 (0.51) | MMP1MMP8MMP2MMP3 | |
| SCHEMBL7357715 | 0.84 | NPC1 (0.49) | MMP1PSMB5MMP8PSMB1PSMB2 | |
| SCHEMBL7354243 | 0.84 | NAALAD2 (0.52) | MMP2 | |
| SCHEMBL8749847 | 0.84 | NAALAD2 (0.52) | MMP2 | |
| SCHEMBL7363512 | 0.83 | MMP3 (0.45) | MMP1PSMB5MMP8PSMB1PSMB2 | |
| SCHEMBL7364715 | 0.82 | L3MBTL1 (0.45) | MMP1MMP8 | |
| SCHEMBL7357664 | 0.82 | ALDH1A1 (0.54) | — | |
| SCHEMBL7357404 | 0.81 | CHRNB2 (0.48) | — | |
| SCHEMBL7363203 | 0.77 | MMP1 (0.40) | MMP1MMP8MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |