Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sarcosine SCHEMBL8008376 | 0.88 | CPB2 (0.44) | CPB2TBXAS1 | |
| SCHEMBL7394043 | 0.82 | CPB2 (0.48) | CPB2TBXAS1 | |
| Arginine SCHEMBL7364644 | 0.81 | ITGB3 (0.40) | FOLH1KISS1RTBXAS1 | |
| SCHEMBL7356951 | 0.79 | CPB2 (0.41) | CPB2 | |
| Arginine SCHEMBL7359466 | 0.75 | F10 (0.36) | CPB2 | |
| Arginine SCHEMBL7364647 | 0.73 | TBXAS1 (0.34) | FOLH1KISS1RTBXAS1 | |
| Arginine SCHEMBL7359381 | 0.69 | SLC1A3 (0.41) | — | |
| Arginine SCHEMBL7359600 | 0.67 | ITGB3 (0.47) | — | |
| Arginine SCHEMBL5598764 | 0.66 | OTC (0.46) | — | |
| Sarcosine SCHEMBL7358185 | 0.65 | ITGB3 (0.47) | CPB2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0801654-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |