Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MITF | O75030 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364978 | 0.88 | MAPT (0.52) | MAPTLMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL7366041 | 0.86 | VCAM1 (0.60) | VCAM1MAPTLMNAHTTNPSR1 | |
| SCHEMBL1467163 | 0.83 | HTT (0.73) | VCAM1MAPTLMNAHTTNPSR1 | |
| SCHEMBL7365348 | 0.81 | KMT2A (0.51) | MAPTLMNAHTTNPSR1SMN1; SMN2 | |
| SCHEMBL51755 | 0.78 | LMNA (0.72) | VCAM1MAPTLMNAHTTMAPK1 | |
| SCHEMBL7362970 | 0.77 | MEN1 (0.49) | MAPTLMNAHTTNPSR1SMN1; SMN2 | |
| SCHEMBL1466306 | 0.77 | HTT (0.58) | VCAM1MAPTLMNAHTTNPSR1 | |
| SCHEMBL7367891 | 0.76 | MEN1 (0.52) | MAPTHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7362977 | 0.76 | ALDH1A1 (0.45) | MAPTLMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL7370453 | 0.76 | ALOX15 (0.50) | HTTSMN1; SMN2NPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |