Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359411 | 0.84 | PSMB1 (0.44) | PSMB1ECE1RENCTSKCAPN1 | |
| SCHEMBL7357213 | 0.79 | ECE1 (0.51) | PSMB1ECE1RENBIRC2 | |
| SCHEMBL7359768 | 0.79 | ECE1 (0.49) | ECE1RENBIRC2 | |
| SCHEMBL9417332 | 0.78 | REN (0.58) | RENCTSKCAPN1MMP3CTSL | |
| SCHEMBL7266563 | 0.76 | CTSK (0.43) | PSMB1RENCTSKCAPN1BIRC2 | |
| SCHEMBL7279380 | 0.76 | FOLH1 (0.47) | BIRC2FOLH1 | |
| SCHEMBL6444948 | 0.76 | ALDH1A1 (0.53) | FOLH1 | |
| SCHEMBL6444952 | 0.76 | ALDH1A1 (0.53) | FOLH1 | |
| SCHEMBL7279383 | 0.76 | FOLH1 (0.47) | BIRC2FOLH1 | |
| SCHEMBL24096149 | 0.75 | EPHX1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |