Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | PYGL | P06737 | 11/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8749847 | 0.82 | NAALAD2 (0.52) | MMP9MMEACENAALAD2 | |
| SCHEMBL7354243 | 0.82 | NAALAD2 (0.52) | MMP9MMEACENAALAD2 | |
| SCHEMBL7358479 | 0.80 | ALOX5 (0.44) | MMP9MMP8MMP14PYGLMMP3 | |
| SCHEMBL7360065 | 0.79 | MMP1 (0.51) | MMP9MMP8MMP3 | |
| SCHEMBL7357715 | 0.78 | NPC1 (0.49) | MMP9MMP8MMP14PSMB1PSMB5 | |
| SCHEMBL7752030 | 0.78 | MMP9 (0.54) | MMP9MMP8MMP14PYGLMMP3 | |
| SCHEMBL6897320 | 0.78 | MMP9 (0.54) | MMP9MMP8MMP14PYGLMMP3 | |
| SCHEMBL7363512 | 0.77 | MMP3 (0.45) | MMP8MMP3PSMB1PSMB5PSMB2 | |
| SCHEMBL6420230 | 0.77 | LMNA (0.41) | MMP9MMP8MMP14MMP3PSMB1 | |
| SCHEMBL7357691 | 0.77 | CTSL (0.45) | MMP8MMP3PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691382-A | ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |