Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363632 | 0.89 | BMPR1B (0.37) | BRD4MAPTHRH3BMPR1BBMPR1A | |
| SCHEMBL7362751 | 0.88 | MAPK14 (0.42) | EGFRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL7365171 | 0.88 | BMPR1B (0.36) | BRD4KDM4EMAPTHRH3BMPR1B | |
| SCHEMBL7362732 | 0.83 | BMPR1B (0.37) | HRH3SRCPIK3CDABL1EGFR | |
| SCHEMBL7364069 | 0.82 | PDE1A (0.39) | BRD4KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL7366115 | 0.80 | USP2 (0.35) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL7367727 | 0.79 | LMNA (0.53) | BRD4KDM4EMAPTHTTCCNE2 | |
| SCHEMBL6818465 | 0.79 | MAPK14 (0.42) | MAPTFGFR1FGFR2FGFR3HRH3 | |
| SCHEMBL6821959 | 0.78 | ADORA1 (0.42) | FGFR1FGFR2FGFR3EGFRADORA1 | |
| SCHEMBL7367567 | 0.78 | MAT2A (0.33) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |