Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.54 |
| ▸ | MMP3 | P08254 | 10/20 | 0.54 |
| ▸ | PDE4A | P27815 | 6/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.54 |
| ▸ | MMP1 | P03956 | 11/20 | 0.54 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19732963 | 0.81 | ALDH1A1 (0.51) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL6414410 | 0.79 | MMP1 (0.58) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL8121331 | 0.78 | MEP1B (0.54) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL7367930 | 0.77 | MEP1B (0.56) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL6415300 | 0.74 | MMP1 (0.68) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL8412098 | 0.73 | MMP1 (0.69) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL7410575 | 0.72 | MEP1B (0.91) | MMP2MMP3MMP1MEP1BMMP13 | |
| SCHEMBL12808152 | 0.71 | ALDH1A1 (0.70) | MMP2MMP3PDE4APDE4BPDE4C | |
| SCHEMBL19732946 | 0.70 | LMNA (0.51) | MMP2MMP1ALDH1A1LMNARAB9A | |
| SCHEMBL6823156 | 0.70 | MMP2 (1.00) | MMP2MMP3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |