Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13687190 | 0.87 | LMNA (0.62) | ALDH1A1LMNAMGLLNPC1 | |
| SCHEMBL18045538 | 0.86 | CRHBP (0.56) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28371306 | 0.84 | PTGDR2 (0.46) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL29280749 | 0.84 | ALDH1A1 (0.62) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6046672 | 0.82 | RAB9A (0.54) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL991783 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL28696202 | 0.82 | LMNA (0.53) | ALDH1A1LMNANPC1 | |
| SCHEMBL28696201 | 0.82 | LMNA (0.53) | ALDH1A1LMNANPC1 | |
| SCHEMBL4973561 | 0.81 | KCNH2 (0.48) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL29280745 | 0.81 | ALDH1A1 (0.62) | CRHBPCRHR2ALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952321-A | Substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0666846-A4 | — | — | 1995-09-20 | — | — | EP | disclosed |
| EP-0666846-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010143-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |