Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.35 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7372438 | 0.87 | GRN (0.45) | CA2CA1F3 | |
| Trifluoroacetic Acid SCHEMBL7368235 | 0.86 | CA2 (0.40) | CA2CA1MRGPRX4 | |
| Trifluoroacetic Acid SCHEMBL7377943 | 0.85 | TMPRSS15 (0.44) | CA2CA1 | |
| SCHEMBL6432917 | 0.84 | TAS1R3 (0.37) | CA2CA1GPR132F2 | |
| Trifluoroacetic Acid SCHEMBL7450905 | 0.83 | CA2 (0.44) | CA2CA1AGTR2GPR132 | |
| Trifluoroacetic Acid SCHEMBL7456725 | 0.82 | PLG (0.47) | NPSR1 | |
| Trifluoroacetic Acid SCHEMBL7372144 | 0.81 | CA1 (0.36) | CA2CA1EGLN1F2 | |
| Trifluoroacetic Acid SCHEMBL7368775 | 0.81 | ITGB3 (0.44) | — | |
| SCHEMBL7370207 | 0.79 | CASP3 (0.46) | CA2CA1 | |
| Trifluoroacetic Acid SCHEMBL7365054 | 0.77 | PLAU (0.45) | NPSR1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |