Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 10/20 | 0.42 |
| ▸ | NPY1R | P25929 | 7/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.42 |
| ▸ | NPY2R | P49146 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368582 | 0.90 | GNPAT (0.48) | SMN1; SMN2HRH4NPY4RNPY1RMMP9 | |
| SCHEMBL7371728 | 0.88 | OPRD1 (0.47) | SMN1; SMN2HRH4NPY4RNPY1RNPY5R | |
| SCHEMBL7374882 | 0.88 | CTSS (0.56) | PSMB5 | |
| SCHEMBL8373858 | 0.82 | HDAC3 (0.42) | SMN1; SMN2HRH4MMP9MMP8MMP14 | |
| SCHEMBL21360283 | 0.80 | GNPAT (0.52) | SMN1; SMN2NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL21167756 | 0.79 | F2 (0.50) | SMN1; SMN2NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL7373235 | 0.78 | CTSS (0.53) | — | |
| SCHEMBL5966682 | 0.78 | PSMB5 (0.49) | PSMB5HRH4 | |
| SCHEMBL30028835 | 0.77 | GNPAT (0.53) | HRH4MMP9MMP8MMP14MME | |
| SCHEMBL11144460 | 0.76 | PSMB1 (0.58) | PSMB5NPY4RNPY1RNPY5RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675899-B1 | NOVEL INHIBITORS OF FACTOR Xa | CORVAS INT INC (US) | 1999-03-17 | — | — | EP | disclosed |
| US-5883077-A | PEPTIDES ALDEHYDE ANALOGUES | CORVAS INTERNATIONAL, INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0675899-A4 | NOVEL INHIBITORS OF FACTOR Xa. | CORVAS INT INC (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0675899-A1 | NOVEL INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994013693-A1 | NOVEL INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1994-06-23 | — | — | WO | disclosed |