Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27343295 | 0.75 | CYP2C9 (0.45) | LMNANPSR1TP53POLBTSHR | |
| SCHEMBL7369553 | 0.75 | HTT (0.47) | LMNAALDH1A1NPSR1HTTPOLB | |
| SCHEMBL6985834 | 0.74 | ALDH1A1 (0.51) | LMNAALDH1A1NPSR1HTTTP53 | |
| SCHEMBL6989453 | 0.72 | KMT2A (0.42) | LMNAALDH1A1NPSR1HTTMAPT | |
| SCHEMBL7370147 | 0.71 | PTGS1 (0.38) | LMNAALDH1A1NPSR1HTTHPGD | |
| SCHEMBL6979697 | 0.71 | CYP1A2 (0.44) | LMNAALDH1A1HTTTP53POLB | |
| SCHEMBL7370829 | 0.70 | NR3C2 (0.44) | ALDH1A1NPSR1TP53POLBMAPT | |
| SCHEMBL6986812 | 0.69 | ALDH1A1 (0.40) | LMNAALDH1A1NPSR1HTTMAPT | |
| SCHEMBL6341690 | 0.68 | PTGS2 (0.70) | CYP2C9PTGS2PTGS1 | |
| SCHEMBL7366842 | 0.68 | NR3C2 (0.43) | LMNANPSR1TP53POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |