Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428868 | 0.90 | RHOC (0.43) | RHOCRHOANOS3NOS1NOS2 | |
| SCHEMBL7458234 | 0.87 | ITGB1 (0.47) | ITGB3ITGAVFPR2P2RX1 | |
| SCHEMBL7449645 | 0.87 | ITGB3 (0.40) | RHOCRHOAITGB3ITGAVNOS3 | |
| SCHEMBL7378843 | 0.87 | ITGB1 (0.47) | ITGB3ITGAVFPR2P2RX1 | |
| SCHEMBL7380932 | 0.86 | RHOC (0.43) | RHOCRHOACTSLNOS3NOS1 | |
| SCHEMBL7382271 | 0.86 | ITGB3 (0.48) | CTSLITGB3ITGAVF2PRSS1 | |
| SCHEMBL7379710 | 0.80 | ITGB3 (0.41) | RHOCRHOACTSLITGB3ITGAV | |
| SCHEMBL7375612 | 0.79 | TRPA1 (0.38) | RHOCRHOAFPR2P2RX1TACR1 | |
| SCHEMBL7375074 | 0.79 | TRPA1 (0.38) | RHOCRHOAFPR2P2RX1TACR1 | |
| SCHEMBL7451739 | 0.77 | ACE (0.45) | RHOCRHOAFPR2PSMB5P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |