Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7444932 | 0.84 | F2 (0.41) | F2PLAUF10GPBAR1 | |
| SCHEMBL7048342 | 0.81 | PLAU (0.41) | PLAUGSTO1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6437619 | 0.80 | PTPRC (0.42) | F2KMT2AF10MEN1 | |
| SCHEMBL6434089 | 0.80 | NR1D1 (0.36) | GSTO1 | |
| SCHEMBL6433230 | 0.78 | ROCK2 (0.41) | F2F10ITGB3ITGA2B | |
| SCHEMBL6433843 | 0.78 | DGAT2 (0.41) | KMT2ASMN1; SMN2F10 | |
| SCHEMBL7371013 | 0.77 | AGTR1 (0.32) | F2KMT2AF10MEN1 | |
| SCHEMBL6434466 | 0.77 | NR1D1 (0.35) | PLAU | |
| SCHEMBL7049621 | 0.77 | PLAU (0.42) | PLAUKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7378316 | 0.76 | GRM2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |