SCHEMBL7379271

SCHEMBL7379271

NC1CN=C(c2ccccc2)c2sccc2N1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 2/20 0.35
NISCH Q9Y2I1 1/20 0.33
NOS3 P29474 1/20 0.31
NOS2 P35228 1/20 0.31
PDPK1 O15530 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C19 P33261 1/20 0.30
KMT2A Q03164 1/20 0.30
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30
GABRA2 P47869 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7319992 0.82 OPRK1 (0.43) OPRK1NISCHKMT2AGABRA1GABRG2
Maleic Acid SCHEMBL7408000 0.75 OPRK1 (0.44) OPRK1KDM4EMEN1ALDH1A1KMT2A
SCHEMBL7308578 0.74 OPRK1 (0.37) OPRK1KMT2A
SCHEMBL7318231 0.70 GABRA1 (0.60) OPRK1ALDH1A1KMT2AGABRA1GABRG2
SCHEMBL20370098 0.68 GABRA1 (0.37) KDM4EMEN1ALDH1A1KMT2AGABRA1
SCHEMBL13898488 0.65 NOS2 (0.37) NOS3NOS2PDPK1KDM4EMEN1
SCHEMBL2980218 0.63 NOS3 (0.54) NOS3NOS2PDPK1
SCHEMBL7379267 0.62 BCAT2 (0.37) OPRK1NOS3NOS2PDPK1ALDH1A1
SCHEMBL7313871 0.60 OPRK1 (0.56) OPRK1NISCHGABRA1GABRG2GABRB3
SCHEMBL13716645 0.59 NISCH (0.37) NISCHKDM4EMEN1ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801651-B1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS HOFFMANN LA ROCHE (CH) 2001-07-11 EP disclosed
US-6174881-B1 USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING HOFFMAN-LA ROCHE INC. 2001-01-16 US disclosed
EP-0801651-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1997-10-22 EP disclosed
WO-1996020941-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1996-07-11 WO disclosed