Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809989 | 0.86 | OPRK1 (0.57) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL8422993 | 0.86 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL2844069 | 0.84 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL13061776 | 0.83 | GABRG2 (0.63) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL637699 | 0.81 | GABRG2 (0.79) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL7313767 | 0.78 | OPRK1 (0.55) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL7307646 | 0.78 | GABRA3 (0.56) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL7351846 | 0.76 | GABRA5 (0.54) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL7317878 | 0.76 | GABRA2 (0.61) | GABRG2GABRB3GABRA3GABRA5GABRA2 | |
| SCHEMBL2841060 | 0.75 | GABRG2 (0.76) | GABRG2GABRB3GABRA3GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377523-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1983-03-22 | — | — | US | disclosed |