Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379862 | 1.00 | GAA (0.51) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL7381321 | 1.00 | GAA (0.51) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL7386971 | 0.82 | LMNA (0.48) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL2125273 | 0.81 | ALDH1A1 (0.46) | GAALMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL7170395 | 0.80 | PTGS2 (0.40) | GAALMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28275642 | 0.80 | TSHR (0.41) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14979298 | 0.80 | L3MBTL1 (0.44) | LMNAMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL18932974 | 0.79 | GAA (0.36) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL18932917 | 0.79 | HDAC3 (0.38) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL1175379 | 0.78 | LMNA (0.46) | LMNAKMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281617-A | Enzyme inhibitor | CORTECH, INC. (US) | 1994-01-25 | — | — | US | claimed |
| US-5281617-A | Enzyme inhibitor | CORTECH, INC. (US) | 1994-01-25 | — | — | US | disclosed |