Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.40 |
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389682 | 0.89 | LIPE (0.44) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL27515642 | 0.88 | SIGMAR1 (0.43) | SIGMAR1LMNAADRA2ANPY5RMCHR1 | |
| SCHEMBL7386030 | 0.85 | ITGB3 (0.44) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7387646 | 0.83 | SIGMAR1 (0.51) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7389131 | 0.82 | THRB (0.42) | SIGMAR1LMNAADRA2ANPY5RMCHR1 | |
| SCHEMBL7422648 | 0.81 | ITGB3 (0.42) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7387547 | 0.80 | ITGB3 (0.44) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7386899 | 0.80 | F10 (0.46) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL27517334 | 0.80 | KMT2A (0.47) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7388205 | 0.79 | ITGB3 (0.42) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |