Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974627 | 0.77 | BACE1 (0.37) | LMNARAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL31427583 | 0.74 | RIPK1 (0.54) | RIPK1SMN1; SMN2PPIDCYP1A2CYP2D6 | |
| SCHEMBL7402519 | 0.74 | NPSR1 (0.35) | RAB9ASMN1; SMN2CYP2C19HTTPOLB | |
| SCHEMBL7401316 | 0.73 | GAA (0.49) | RIPK1LMNASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4949794 | 0.72 | — | — | |
| SCHEMBL1901972 | 0.72 | RIPK1 (0.43) | RIPK1LMNARAB9ASMN1; SMN2PPID | |
| SCHEMBL7394877 | 0.71 | MCL1 (0.47) | RIPK1LMNASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL8386601 | 0.71 | SIGMAR1 (0.37) | SMN1; SMN2POLB | |
| SCHEMBL14336905 | 0.70 | ALDH1A1 (0.49) | RIPK1SMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4705631 | 0.70 | ADRB2 (0.38) | LMNARAB9ASMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711162-A4 | IMIDAZOLE 5-POSITION SUBSTITUTED ANGIOTENSIN II ANTAGONISTS | DU PONT MERCK PHARMA (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5545651-A | HYPOTENSIVE AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0711162-A1 | IMIDAZOLE 5-POSITION SUBSTITUTED ANGIOTENSIN II ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-05-15 | — | — | EP | disclosed |
| US-5395844-A | Hypotensive agents; congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-03-07 | — | — | US | disclosed |
| WO-1994028896-A1 | IMIDAZOLE 5-POSITION SUBSTITUTED ANGIOTENSIN II ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-12-22 | — | — | WO | disclosed |