SCHEMBL739977

SCHEMBL739977

COC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F2 P00734 13/20 0.44
F10 P00742 13/20 0.44
PRSS1 P07477 13/20 0.44
PDK2 Q15119 2/20 0.40
SLC6A4 P31645 2/20 0.40
SLC6A3 Q01959 2/20 0.40
LTB4R Q15722 1/20 0.39
LTB4R2 Q9NPC1 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
RECQL P46063 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL739985 0.91 SLC6A3 (0.49) F2F10PRSS1PDK2SLC6A4
SCHEMBL737445 0.90 DHODH (0.38) F2F10PRSS1PDK2LTB4R
SCHEMBL2529138 0.88 PDK2 (0.45) F2F10PRSS1PDK2SLC6A4
SCHEMBL23778641 0.87 KDM4E (0.39) F2F10PRSS1PDK2SLC6A4
SCHEMBL362563 0.87 KDM4E (0.39) F2F10PRSS1PDK2SLC6A4
SCHEMBL3108151 0.87 PDK2 (0.36) F2F10PRSS1PDK2CA1
SCHEMBL738671 0.86 PDK2 (0.36) F2F10PRSS1PDK2SLC6A4
SCHEMBL11960920 0.86 ABL1 (0.44) F2F10PRSS1PDK2CA1
SCHEMBL738428 0.86 NOTUM (0.39) F2F10PRSS1PDK2CA1
SCHEMBL738679 0.86 CA1 (0.37) F2F10PRSS1PDK2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 627 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024127026-A1 MEMBRANE FILTRATION-ASSISTED SOLUTION PHASE OLIGONUCLEOTIDE SYNTHESIS Exactmer Limited (GB) 2024-06-20 WO claimed
US-20240075150-A1 CONJUGATES COMPRISING REVERSIBLE LINKERS AND USES THEREOF ASCENDIS PHARMA A/S (DK) 2024-03-07 US claimed
EP-4313154-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD Therapeutics Limited (HK) 2024-02-07 EP claimed
US-20230331934-A1 NEW HYDROGELS LEIBNIZ-INSTITUT FÜR NEUE MATERIALIEN GEMEINNÜTZIGE GMBH (DE) 2023-10-19 US claimed
EP-4218795-A2 PTH COMPOUNDS WITH LOW PEAK-TO-TROUGH RATIOS Ascendis Pharma Bone Diseases A/S (DK) 2023-08-02 EP claimed
EP-4192508-A1 CONJUGATES COMPRISING REVERSIBLE LINKERS AND USES THEREOF Ascendis Pharma A/S (DK) 2023-06-14 EP claimed
US-20230110994-A1 CONJUGATES UNDERGOING INTRAMOLECULAR REARRANGEMENTS ASCENDIS PHARMA A/S (DK) 2023-04-13 US claimed
US-20230065814-A1 CONJUGATES OF-ELECTRON-PAIR-DONATING HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS ASCENDIS PHARMA A/S (DK) 2023-03-02 US claimed
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2022-12-22 US claimed
EP-4084872-A1 CONJUGATES UNDERGOING INTRAMOLECULAR REARRANGEMENTS Ascendis Pharma A/S (DK) 2022-11-09 EP claimed
US-20100267886-A1 USE OF HIGHLY BRANCHED POLYMERS IN POLYMER DISPERSIONS FOR GLOSS COLOURS BASF SE (DE) 2010-10-21 US claimed
US-20090093597-A1 SYNTHESIS OF PARTICLES IN DENDRITIC STRUCTURES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) 2009-04-09 US claimed
JP-2008545621-A 2008-12-18 JP claimed
EP-1877103-A2 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY Dendritic Nanotechnologies, Inc. (US) 2008-01-16 EP claimed
US-20070298006-A1 Dendritic Polymers With Enhanced Amplification and Interior Functionality DENDRITIC NANOTECHNOLOGIES, INC. (US) 2007-12-27 US claimed
US-20070110810-A1 Transdermal drug delivery systems, devices, and methods employing hydrogels TRANSCUTANEOUS TECHNOLOGIES INC. (JP) 2007-05-17 US claimed
WO-2007041119-A1 TRANSDERMAL DRUG DELIVERY SYSTEMS, DEVICES, AND METHODS EMPLOYING HYDROGELS TTI ELLEBEAU, INC. (JP) 2007-04-12 WO claimed
WO-2006115547-A2 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY DENDRITIC NANOTECHNOLOGIES, INC. (US) 2006-11-02 WO claimed
US-6030738-A HAVING CHARGE CONTROL PROPERTIES AND HIGH THERMAL STABILITY; COMPOUNDS ARE PREFERENTIALLY WITHOUT INHERENT COLOR AND HAVE GOOD DISPERSIBILITY IN CUSTOMARY TONER, POWDER COATING AND ELECTRET BINDERS CLARIANT GMBH (DE) 2000-02-29 US claimed
US-5738864-A COVALENT COUPLING THROUGH LINKING SPACER GROUPS TO MACROMOLECULES THAT CAN SERVE AS RELATIVELY INERT POLYMERIC DRUG CARRIERS IN BIOLOGICAL SYSTEMS; SIDE EFFECT REDUCTION EUROPEAN COMMUNITY (DE) 1998-04-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070298006-A1 Dendritic Polymers With Enhanced Amplification and Interior Functionality MYD88, TLR3, TMEM97 F2 3712/4885F10 3424/4885PRSS1 2509/4885
US-20240075150-A1 CONJUGATES COMPRISING REVERSIBLE LINKERS AND USES THEREOF CD44, PTMS, MSN F2 3811/4885F10 3853/4885PRSS1 4240/4885
US-20230110994-A1 CONJUGATES UNDERGOING INTRAMOLECULAR REARRANGEMENTS BCR, DHFR, ABL1 F2 1595/4885F10 2458/4885PRSS1 3908/4885
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, SSB, DNPEP F2 1812/4885F10 1337/4885PRSS1 1861/4885
US-20230065814-A1 CONJUGATES OF-ELECTRON-PAIR-DONATING HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS NQO1, NCL, ABCB1 F2 1559/4885F10 3670/4885PRSS1 4542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.