SCHEMBL7411529

SCHEMBL7411529

CN(C)C1CCc2[nH]c3c(COC(=O)c4ccc(C(F)(F)F)cc4)cccc3c2C1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR1F P30939 1/20 0.43
HTR6 P50406 5/20 0.40
TDP1 Q9NUW8 1/20 0.37
HTR1A P08908 2/20 0.35
HTR7 P34969 2/20 0.35
MMP12 P39900 2/20 0.35
MMP1 P03956 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.34
GPBAR1 Q8TDU6 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
TACR1 P25103 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
ATM Q13315 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7411494 0.90 HTR1F (0.41) HTR1FHTR6KDM4EALDH1A1LMNA
SCHEMBL7412016 0.90 HTR1F (0.40) HTR1FHTR6
SCHEMBL7412348 0.79 HTR1F (0.56) HTR1FHTR1AKDM4EALDH1A1LMNA
SCHEMBL7409286 0.78 HTR1F (0.37) HTR1FHTR6ALDH1A1
SCHEMBL7407854 0.77 CHRM3 (0.44) HTR1FHTR1AHTR7
SCHEMBL7410521 0.77 HTR1F (0.41) HTR1FHTR6HTR1AHTR7ALDH1A1
Hydrochloric Acid SCHEMBL7407442 0.76 HTR1F (0.41) HTR1FHTR6HTR1AHTR7ALDH1A1
SCHEMBL7417232 0.75 BRD4 (0.41) HTR1FTDP1MMP12MMP1ALDH1A1
SCHEMBL7417151 0.75 HTR1F (0.47) HTR1FHTR6HTR1AHTR7MMP12
SCHEMBL7409574 0.74 ALDH1A1 (0.45) HTR1FALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed
US-4257952-A PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES STERLING DRUG INC. (US) 1981-03-24 US disclosed
US-4172834-A ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS STERLING DRUG INC. (US) 1979-10-30 US disclosed
US-4062864-A ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1977-12-13 US disclosed
US-3959309-A ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1976-05-25 US disclosed