Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ME3 | Q16798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141371 | 0.88 | POLB (0.46) | ABL1TRPV1DEGS1POLBCHRM2 | |
| Trifluoroacetic Acid SCHEMBL7376343 | 0.87 | ME3 (0.48) | ABL1DEGS1POLBMAPTMAPK1 | |
| Trifluoroacetic Acid SCHEMBL7413403 | 0.82 | BACE1 (0.45) | HTR6POLB | |
| SCHEMBL7371765 | 0.80 | ME3 (0.54) | ABL1POLBMAPTMAPK1ME3 | |
| Trifluoroacetic Acid SCHEMBL7522281 | 0.79 | ALDH1A1 (0.49) | MAPT | |
| Trifluoroacetic Acid SCHEMBL7379635 | 0.78 | TRPV1 (0.45) | ABL1TRPV1MAPTMAPK1CYP2C9 | |
| SCHEMBL8143794 | 0.75 | HTR6 (0.46) | HTR6MAPTCYP1A2KDM4EHSD17B10 | |
| SCHEMBL8142733 | 0.74 | TRPV1 (0.47) | ABL1TRPV1MAPTMAPK1CYP2C9 | |
| SCHEMBL8148485 | 0.74 | ALDH1A1 (0.48) | MAPT | |
| SCHEMBL7376347 | 0.72 | ALDH1A1 (0.43) | ABL1DEGS1MAPTMAPK1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069143-A | Fibrinogen receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0885213-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0885213-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997025323-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |