Oleanolic_Acid

Oleanolic_Acid

SCHEMBL741472

CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 12/20 1.00
PTPN2 P17706 4/20 1.00
F3 P13726 4/20 1.00
POLB P06746 3/20 1.00
USP7 Q93009 3/20 1.00
AKR1B10 O60218 3/20 1.00
GPBAR1 Q8TDU6 3/20 1.00
PSMB11 A5LHX3 2/20 1.00
PSMA7 O14818 2/20 1.00
PLA2G1B P04054 2/20 1.00
PTPRC P08575 2/20 1.00
PTPRF P10586 2/20 1.00
PSMB1 P20618 2/20 1.00
CES1 P23141 2/20 1.00
ACP1 P24666 2/20 1.00
PSMA1 P25786 2/20 1.00
PSMA2 P25787 2/20 1.00
PSMA3 P25788 2/20 1.00
PSMA4 P25789 2/20 1.00
PSMB8 P28062 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oleanolic_Acid SCHEMBL15714063 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL12337275 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL18420569 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL13425080 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL13395360 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL16153016 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL24916648 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL21892159 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL22009261 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7
Oleanolic_Acid SCHEMBL20904290 1.00 PTPN1 (1.00) PTPN1PTPN2F3POLBUSP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2260851-A1 USE OF PENTACYCLIC TRITERPENE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOUND INTENDED FOR THE TREATMENT OF MULTIPLE SCLEROSIS Consejo Superior De Investigaciones Científicas (ES) 2010-12-15 EP claimed
US-20260083753-A1 Compositions for the Treatment of Metabolic Syndrome and Other Metabolic Disorders, and Methods of Manufacture FLORIDA RES GROUP LLC (US) 2026-03-26 US disclosed
US-11633407-B2 Botanical extracts and compounds from Schinus plants and methods of use EMORY UNIVERSITY (US) 2023-04-25 US disclosed
US-20210315906-A1 Botanical Extracts and Compounds from Schinus Plants and Methods of Use EMORY UNIVERSITY 2021-10-14 US disclosed
EP-2786757-B1 2-SUBSTITUTED OLEANOLIC ACID DERIVATIVE, METHOD PREPARING FOR SAME, AND APPLICATION THEREOF HANGZHOU BENSHENG PHARMACEUTICAL CO LTD (CN) 2017-08-16 EP disclosed
US-9156801-B2 2-substituted oleanolic acid derivative, method preparing for same, and application thereof HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD. (CN) 2015-10-13 US disclosed
US-9156801-B2 2-substituted oleanolic acid derivative, method preparing for same, and application thereof HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD. (CN) 2015-10-13 US disclosed
US-20140343064-A1 2-SUBSTITUTED OLEANOLIC ACID DERIVATIVE, METHOD PREPARING FOR SAME, AND APPLICATION THEREOF Hanghzhou Bensheng Pharmaceutical Co., Ltd (CN) 2014-11-20 US disclosed
US-20140343064-A1 2-SUBSTITUTED OLEANOLIC ACID DERIVATIVE, METHOD PREPARING FOR SAME, AND APPLICATION THEREOF Hanghzhou Bensheng Pharmaceutical Co., Ltd (CN) 2014-11-20 US disclosed
EP-2786757-A1 2-SUBSTITUTED OLEANOLIC ACID DERIVATIVE, METHOD PREPARING FOR SAME, AND APPLICATION THEREOF Hangzhou Bensheng Pharmaceutical Co., Ltd. (CN) 2014-10-08 EP disclosed
EP-2431041-A1 PHARMACEUTICAL COMPOSITION FOR TREATING CARDIOVASCULAR DISORDER AND USE THEREOF Chengdu Kanghong Pharmaceutical Co., Ltd. (CN) 2012-03-21 EP disclosed
EP-2260851-A1 USE OF PENTACYCLIC TRITERPENE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOUND INTENDED FOR THE TREATMENT OF MULTIPLE SCLEROSIS Consejo Superior De Investigaciones Científicas (ES) 2010-12-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210315906-A1 Botanical Extracts and Compounds from Schinus Plants and Methods of Use BROX, C5, SYMPK PTPN1 2016/4885PTPN2 1662/4885F3 1684/4885
US-11633407-B2 Botanical extracts and compounds from Schinus plants and methods of use BROX, C5, SYMPK PTPN1 2016/4885PTPN2 1662/4885F3 1684/4885
US-20260083753-A1 Compositions for the Treatment of Metabolic Syndrome and Other Metabolic Disorders, and Methods of Manufacture SLC2A4, NPC1L1, SLC2A3 PTPN1 3677/4885PTPN2 3914/4885F3 1658/4885
US-20140343064-A1 2-SUBSTITUTED OLEANOLIC ACID DERIVATIVE, METHOD PREPARING FOR SAME, AND APPLICATION THEREOF CYP27A1, SOAT2, OSBP2 PTPN1 4010/4885PTPN2 2908/4885F3 1853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.