Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 4/20 | 0.44 |
| ▸ | KMO | O15229 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414012 | 0.89 | KMO (0.43) | WEE1KMOALDH1A1CHEK1SRC | |
| SCHEMBL10747226 | 0.82 | TBXAS1 (0.42) | KMOALDH1A1SRCKDM4EPOLB | |
| SCHEMBL10621833 | 0.81 | KMO (0.57) | KMOALDH1A1KDM4EPOLBL3MBTL1 | |
| Iodide SCHEMBL10619045 | 0.80 | KMO (0.56) | KMOALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL7412024 | 0.76 | WEE1 (0.50) | WEE1KMOALDH1A1CHEK1SRC | |
| SCHEMBL7405656 | 0.75 | FABP4 (0.45) | WEE1ALDH1A1CHEK1SRCKDM4E | |
| SCHEMBL7405683 | 0.73 | KMO (0.45) | WEE1KMOALDH1A1CHEK1SRC | |
| SCHEMBL7407798 | 0.73 | WEE1 (0.47) | WEE1KMOALDH1A1CHEK1SRC | |
| SCHEMBL7405772 | 0.70 | DYRK1A (0.51) | KMOALDH1A1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL7418131 | 0.70 | KMO (0.41) | WEE1KMOALDH1A1CHEK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |