Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 11/20 | 0.56 |
| ▸ | MMP3 | P08254 | 9/20 | 0.56 |
| ▸ | PDE4A | P27815 | 4/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.56 |
| ▸ | MMP1 | P03956 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 3/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.54 |
| ▸ | MMP13 | P45452 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461425 | 0.85 | MEP1B (0.56) | MEP1BMMP2MMP3PDE4APDE4B | |
| SCHEMBL7411095 | 0.84 | MMP1 (0.65) | SMN1; SMN2MMP2MMP3PDE4AMMP1 | |
| SCHEMBL7418100 | 0.84 | MMP2 (0.55) | SMN1; SMN2MMP2MMP3MMP1ALDH1A1 | |
| SCHEMBL7413723 | 0.81 | MEP1B (0.62) | MEP1BMMP2MMP3PDE4APDE4B | |
| SCHEMBL6324010 | 0.81 | ALDH1A1 (0.62) | SMN1; SMN2MMP2MMP3MMP1ALDH1A1 | |
| SCHEMBL6324013 | 0.81 | ALDH1A1 (0.62) | SMN1; SMN2MMP2MMP3MMP1ALDH1A1 | |
| SCHEMBL6321535 | 0.81 | ALDH1A1 (0.62) | SMN1; SMN2MMP2MMP3MMP1ALDH1A1 | |
| SCHEMBL7410702 | 0.81 | PDE4A (0.67) | MEP1BMMP2MMP3PDE4APDE4B | |
| SCHEMBL23518077 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2MMP2MMP3MMP1ALDH1A1 | |
| SCHEMBL7417565 | 0.78 | MMP9 (0.64) | SMN1; SMN2MMP2MMP3MMP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |