Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.67 |
| ▸ | MMP2 | P08253 | 7/20 | 0.67 |
| ▸ | MMP3 | P08254 | 7/20 | 0.67 |
| ▸ | MMP1 | P03956 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.52 |
| ▸ | EEF2K | O00418 | 2/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419745 | 0.86 | MMP1 (0.59) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL2454202 | 0.85 | MMP9 (0.58) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7418486 | 0.85 | ATM (0.57) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7416702 | 0.81 | MEP1B (0.58) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL6823156 | 0.80 | MMP2 (1.00) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7461425 | 0.80 | MEP1B (0.56) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7373322 | 0.79 | MMP9 (0.57) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7373320 | 0.79 | MMP9 (0.57) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL29183283 | 0.78 | ALDH1A1 (0.55) | ALDH1A1ATML3MBTL1KDM4ECYP3A4 | |
| SCHEMBL7383649 | 0.77 | SLC1A3 (0.59) | PDE4APDE4BPDE4CPDE4DMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |