Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.53 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.53 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.53 |
| ▸ | ITGAV | P06756 | 3/20 | 0.53 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.51 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.51 |
| ▸ | ITGAL | P20701 | 1/20 | 0.51 |
| ▸ | KLK1 | P06870 | 7/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.49 |
| ▸ | PLG | P00747 | 6/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 5/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327252 | 0.85 | LOXL2 (0.54) | KLK1PLGKLKB1PLAUPLAT | |
| Hydrochloric Acid SCHEMBL7443406 | 0.83 | LOXL2 (0.52) | KLK1PLGKLKB1PLAUPLAT | |
| Trifluoroacetic Acid SCHEMBL5311009 | 0.83 | ITGB3 (0.54) | ITGB3ITGB1ITGA5ITGAVITGB5 | |
| Phenylguanidine SCHEMBL7425328 | 0.82 | CHIT1 (0.49) | KLK1KLK5PLGKLKB1PLAU | |
| Trifluoroacetic Acid SCHEMBL30725604 | 0.81 | KLK1 (0.51) | KLK1KLK5PLGKLKB1PLAU | |
| Trifluoroacetic Acid SCHEMBL5313227 | 0.79 | MLYCD (0.57) | ITGB3ITGB1ITGA5ITGAVITGB5 | |
| Trifluoroacetic Acid SCHEMBL17894404 | 0.78 | EPHX2 (0.53) | KLK1KLK5 | |
| SCHEMBL18227059 | 0.78 | CA12 (0.57) | ITGB3ITGB1ITGA5ITGAVITGB5 | |
| Trifluoroacetic Acid SCHEMBL7344122 | 0.78 | PLAU (0.84) | KLK1KLK5PLGKLKB1PLAU | |
| Trifluoroacetic Acid SCHEMBL29143010 | 0.77 | KLK1 (0.49) | KLK1KLK5PLGKLKB1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |