Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409578 | 0.82 | CHRNA3 (0.45) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL7409573 | 0.82 | CHRNA3 (0.45) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL6588716 | 0.81 | CHRNA3 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL7472876 | 0.81 | CHRNA3 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL8437928 | 0.79 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL8435310 | 0.79 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL25319155 | 0.78 | GPR119 (0.38) | GPR119 | |
| SCHEMBL384986 | 0.76 | GPR119 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL29757897 | 0.76 | GPR119 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL7524902 | 0.75 | GPR119 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |