Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410781 | 0.95 | CASP1 (0.52) | CASP1ELANECTSLCTSSCTSK | |
| SCHEMBL7419148 | 0.92 | CTSL (0.49) | CASP1ELANECTSLRENCTSB | |
| SCHEMBL7411626 | 0.89 | CASP1 (0.47) | CASP1ELANERENCA2CASP3 | |
| SCHEMBL7415572 | 0.84 | CASP1 (0.54) | CASP1CTSDCASP3CTSB | |
| SCHEMBL7416124 | 0.80 | CASP3 (0.49) | CASP1ELANECTSLCTSSREN | |
| SCHEMBL9579040 | 0.80 | CASP3 (0.46) | CASP1ELANECTSLCTSSREN | |
| SCHEMBL7410782 | 0.79 | CASP1 (0.48) | CASP1ELANEMMP3CA2 | |
| SCHEMBL7423302 | 0.79 | CASP1 (0.52) | CASP1ELANECTSLCTSDCASP3 | |
| SCHEMBL7414133 | 0.79 | CTSB (0.56) | CTSLCTSSCTSKRENCASP3 | |
| SCHEMBL7420909 | 0.79 | CTSB (0.56) | CTSLCTSSCTSKRENCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992017176-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-10-15 | — | — | WO | claimed |
| US-5256677-A | Enzyme inhibitor for treating acquired immune deficiency syndrome | ABBOTT LABORATORIES (US) | 1993-10-26 | — | — | US | disclosed |
| WO-1992017176-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-10-15 | — | — | WO | disclosed |
| US-5151438-A | Enzyme inhibitors for treatment of aids | ABBOTT LABORATORIES (US) | 1992-09-29 | — | — | US | disclosed |