Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425766 | 1.00 | PSMB5 (0.49) | PSMB5MKNK1MKNK2GPR88NTSR1 | |
| SCHEMBL7427409 | 0.88 | MMP12 (0.46) | GPR88MMP12CTSLCTSSCTSK | |
| SCHEMBL7420384 | 0.88 | MMP12 (0.46) | GPR88MMP12CTSLCTSSCTSK | |
| SCHEMBL7421351 | 0.82 | MMP13 (0.48) | PSMB5ADAMTS4 | |
| SCHEMBL7424796 | 0.82 | HPGD (0.38) | GPR88 | |
| SCHEMBL7425601 | 0.81 | MCHR1 (0.50) | GPR88 | |
| SCHEMBL7378945 | 0.80 | MEN1 (0.48) | — | |
| SCHEMBL7424495 | 0.80 | HCAR2 (0.43) | GPR88CTSLCTSK | |
| SCHEMBL7419478 | 0.78 | MMP2 (0.42) | AKR1C2 | |
| SCHEMBL7424015 | 0.78 | GPR88 (0.42) | GPR88CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |