Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251645 | 0.88 | ALOX5 (0.43) | ALOX5LMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL8555747 | 0.83 | PLK1 (0.39) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8554409 | 0.80 | LMNA (0.47) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7707823 | 0.79 | ALOX5 (0.44) | ALOX5LMNASMN1; SMN2GAARAB9A | |
| SCHEMBL8555588 | 0.79 | SMN1; SMN2 (0.47) | ALOX5LMNASMN1; SMN2ALDH1A1PDE3B | |
| SCHEMBL8551585 | 0.78 | SMN1; SMN2 (0.48) | ALOX5LMNASMN1; SMN2ALDH1A1PDE3B | |
| SCHEMBL8554263 | 0.77 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2ALDH1A1PDE3B | |
| SCHEMBL6930961 | 0.77 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2ALDH1A1PDE3B | |
| SCHEMBL8551861 | 0.77 | ALOX5 (0.41) | ALOX5LMNASMN1; SMN2ALDH1A1PDE3B | |
| SCHEMBL8557456 | 0.75 | LMNA (0.48) | ALOX5LMNASMN1; SMN2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |