Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424550 | 0.83 | ALOX5 (0.39) | CNR1CNR2PDE3BPDE3AALOX5 | |
| SCHEMBL251645 | 0.82 | ALOX5 (0.43) | PDE3BPDE3AALOX5LMNASMN1; SMN2 | |
| SCHEMBL8553612 | 0.78 | PDE3B (0.43) | CNR1PDE3BPDE3AALOX5LMNA | |
| SCHEMBL7707823 | 0.76 | ALOX5 (0.44) | CNR1PDE3BPDE3AALOX5LMNA | |
| SCHEMBL5797940 | 0.76 | PPARG (0.49) | ALOX5PPARGMCL1 | |
| SCHEMBL8555588 | 0.74 | SMN1; SMN2 (0.47) | PDE3BPDE3AALOX5LMNASMN1; SMN2 | |
| SCHEMBL8557456 | 0.73 | LMNA (0.48) | PDE3BPDE3AALOX5LMNASMN1; SMN2 | |
| SCHEMBL8551585 | 0.73 | SMN1; SMN2 (0.48) | PDE3BPDE3AALOX5LMNASMN1; SMN2 | |
| SCHEMBL8557542 | 0.72 | LMNA (0.42) | PDE3BPDE3ALMNASMN1; SMN2GRIN1 | |
| SCHEMBL8554263 | 0.72 | ALOX5 (0.39) | CNR1PDE3BPDE3AALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |