Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ECE1 | P42892 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426438 | 0.88 | L3MBTL1 (0.34) | ALDH1A1RAB9AL3MBTL1MAPK1ECE1 | |
| SCHEMBL7426234 | 0.87 | LOXL2 (0.47) | ALDH1A1RAB9AL3MBTL1MAPK1HDAC3 | |
| SCHEMBL7425594 | 0.86 | LOXL2 (0.46) | ALDH1A1RAB9AL3MBTL1MAPK1HDAC3 | |
| SCHEMBL7423323 | 0.84 | BCHE (0.33) | HDAC1HDAC6 | |
| SCHEMBL7426729 | 0.80 | TP53 (0.39) | ALDH1A1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7417287 | 0.80 | NR4A2 (0.36) | NR4A2 | |
| SCHEMBL7426906 | 0.79 | HDAC1 (0.37) | HDAC1HDAC6 | |
| SCHEMBL7417819 | 0.74 | HDAC1 (0.34) | HDAC1HDAC6MAPT | |
| SCHEMBL5869832 | 0.73 | ACE2 (0.38) | ALDH1A1RAB9AL3MBTL1MAPK1HDAC3 | |
| SCHEMBL7382337 | 0.73 | MAPT (0.41) | ALDH1A1RAB9ASMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |